FREE SHIPPING in NL from € 15,- Delivery in EU within 1-3 working days* Discrete packaging
You are here: Caryophyllene
Show all subjects


1. Caryophyllene


β-caryophyllene is a sesquiterpene found in many plants such as Thai basil, cloves, cinnamon leaves and black pepper, it’s also present in small quantities in lavender. The aroma is described as peppery, woody and/or spicy. Caryophyllene is the only terpene known to interact with the endocannabinoid system (CB2). Studies show that β- caryophyllene may play a very valuable role in cancer treatments. Research shows that β-caryophyllene selectively binds to the CB2 receptor and is a functional CB2 agonist. Furthermore, β-caryophylene was identified as functionally non-psychoactive CB2 receptor ligand in food products and as macrocyclic anti-inflammatory cannabinoid in cannabis.

The Fine/Rosenfeld pain study in 2013 showed that other phytocannabinoids in combination, in particular cannabidiol (CBD) and β-caryophylene administered by oral route, appear to be promising candidates for the treatment of chronic pain due to their high safety and low side effects.

The Horváth et al study in 2012 suggests that β-caryophylene, via a CB2 receptor-dependent route, can be an excellent therapeutic tool to prevent nephrotoxicity (toxicity to the kidneys) caused by chemotherapy drugs used in treating cancer, such as Cisplatin.

The study by Kristiniak et al., also published in 2012, investigated the chemical composition of essential oil isolated from black pepper, of which caryophyllene is an important component and studied the pharmacological properties. Black pepper oil was found to possess antioxidant, anti-inflammatory and antinociceptive properties.This suggests that caryophyllene-rich strains can be useful in the treatment of a number of medical problems, such as arthritis and neuropathic pain.

β-caryophyllene is mainly used for chewing gum in combination with other spicy mixtures or citrus fruits.

FREE shipping in NL from € 15,- Delivery in EU within 1-3 working days* Always a free gift with your order
Are you 18 years or older?

Please take into account the legislation of the country to which you want your orders to be sent. Our webshop is subject to Dutch law.

By clicking Continue, you confirm that you are 18 years of age or older and that you have taken note of and agree to our warning regarding applicable legislation.

Continue Leave

You can order in our webshop as usual.
We treat your order with the utmost care.

physilcal Sirius Smart Shops are also OPEN
in Roermond NL Zwartbroekstraat 35 
and Maastricht NL Oude Tweebergenpoort 7A 

Thank you very much for your trust in us!

Je gebruikt een oude browser. We kunnen daarom niet garanderen dat de website naar behoren functioneert. Update je browser of gebruik een andere voor een betere gebruikservaring.